Sirolimus Improves Early Microcirculation, but Impairs Regeneration After Pancreatic Ischemia-Reperfusion Injury
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چکیده
منابع مشابه
DPP4 inhibition improves functional outcome after renal ischemia-reperfusion injury.
Dipeptidyl peptidase 4 (DPP4) is an exopeptidase which modulates the function of its substrates, among which are insulin-releasing incretins. DPP4 inhibitors are currently used to improve glucose tolerance in type 2 diabetes patients. Inhibition of DPP4 exhibits protective effects on ischemia-reperfusion injury (IRI) of the heart and lung. As DPP4 and its substrates are also expressed in the ki...
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OBJECTIVE We used the hamster cheek pouch microcirculation to investigate the effects of melatonin (ME) on ischemia reperfusion (I-R) injury by in vivo microscopy. ME is a hormone produced by the pineal gland and is the most powerful and effective hydroxyl radical scavenger detected to date in vitro. The second aim was to determine the scavenger effect of ME in cheek pouch microcirculation when...
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Introduction: Orexins are novel neuropeptides that are localized in neurons in the lateral hypothalamus. They are implicated in a wide variety of physiological functions. Orexin peptides and receptors are found in many peripheral organs such as kidneys. It has been demonstrated that exogenous orexin-A can induce protective effects against ischemia–reperfusion injury in many organs. The goal ...
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this study investigated the effect of berberine on the hepatic dysfunction and histological damage induced by renal ischaemia/ reperfusion (i/r) at an early stage. there were four groups (n=7). in ber+i/r group, rats received berberine (ber; 15 mg/kg/day) orally for 7 days before induction of ischemia. i/r group received distilled water orally for 7 days. in sham and ber+sham groups in which ar...
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For now the best-established and accepted theory in Alzheimer's disease (AD) etiology by most scientists is the "amyloid theory", as the main molecular factor of neurodegeneration in AD. We critically review these observations and highlight inconsistencies between the predictions of the "amyloid hypothesis" and the published data. The research of neurobiology of AD, now more than ever, needs an...
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ژورنال
عنوان ژورنال: American Journal of Transplantation
سال: 2007
ISSN: 1600-6135,1600-6143
DOI: 10.1111/j.1600-6143.2006.01589.x